Resource title

Compound Optimal Designs for Percentile Estimation in Dose-Response Models with Restricted Design Intervals

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Resource description

In dose-response studies, the dose range is often restricted due to ethics concerns over drug toxicity and/or efficacy, particularly when human subjects are involved. We present locally optimal designs for the estimation of several percentiles simultaneously on restricted as well as unrestricted design intervals. Our results are applicable to most of the commonly applied link functions with respect to the model under consideration. This work is a generalization of Dai (2000) where he showed that the same results hold for the logit model using Elfving?s approach on trace optimal design (Elfving, 1952).

Resource author

Holger Dette, Stefanie Biedermann, Wei Zhu

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Resource language

eng

Resource content type

text/html

Resource resource URL

http://hdl.handle.net/10419/22593

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Adapt according to the presented license agreement and reference the original author.