Resource title

Optimal design for goodness-of-fit of the Michaelis-Menten enzyme kinetic function

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Resource description

We construct efficient designs for the Michaelis-Menten enzyme kinetic model capable of checking model assumption. An extended model, called EMAX model is also considered for this purpose. This model is widely used in pharmacokinetics and reduces to the Michaelis- Menten model for a specific choice of the parameter setting. Our strategy is to find efficient designs for estimating the parameters in the EMAX model and at the same time test the validity of the Michaelis-Menten model against the EMAX model by maximizing a minimum of the D- or D1-efficiencies taken over a range of values for the nonlinear parameters. In addition, we show that the designs obtained from maximizing the D-efficiencies are (i) efficient for estimating parameters in the EMAX model or the Michaelis-Menten model, (ii) efficient for testing the Michaelis-Menten model against the EMAX model and (iii) robust with respect to misspecification of the unknown parameters.

Resource author

Weng Kee Wong, Viatcheslav B. Melas, Holger Dette

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Resource publish date

Resource language

eng

Resource content type

text/html

Resource resource URL

http://hdl.handle.net/10419/22536

Resource license

Adapt according to the presented license agreement and reference the original author.